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KMID : 0370019940080000027
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Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.27 ~ p.37
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Antimicrobal Activities and Pharmacokinetics of N,N´-Oxalyl bis［1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid］
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Abstract
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Norfloxacin is a fluoroquinolone antibiotic with wide spread therapeutic application because of its broad spectrum if antibacterial activity, oral effectiveness, and low incidence of serious adverse effects. Studies over the past few years established several fluoroquinolones, including norfloxain. But they have often resistance and some of the problem of pharmacokinetics.
In order to find more potent and safe drugs, a bivalent ligand was synthesized by the reaction of norfloxacin with oxaylchloride, and evaluated for MICs and the serum concentrations were determined by HPLC.
Oxalyl-bis-norfloxacin was shown more potent than norfloxacin in MICs at Pseudomonas aeruginosa snd Klebsiella pneumoniae.
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